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Novus/Q-VD-OPH Inhibitor Peptide/NBP2-29391-5mg
产品编号：NBP2-29391-5mg
市  场 价：¥19580.00
场      地：美国(厂家直采)
产品分类： 蛋白类>多肽>多肽合成>
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美  元  价：$979.00
品      牌： Novus
公      司：Novus Biologicals
公司分类：
Novus/Q-VD-OPH Inhibitor Peptide/NBP2-29391-5mg
商品介绍
Immunogen
Q-VD-OPH is a cell permeable caspase peptide inhibitor. Caspase inhibitors irreversibly bind to the catalytic site of caspase proteases and inhibit apoptosis. Caspase inhibitors may be broad spectrum, inhibiting multiple caspases, or may preferentially inhibit particular caspases. Z-VAD-FMK, BOC-D-FMK, and Q-VD-OPHare examples of broad spectrum or pan caspase inhibitors. In contrast Z-DEVD-FMKpreferentially inhibits caspases 3 and 7, Z-IETD-FMKpreferentially inhibits caspase 8, Z-LEHD-FMKpreferentiailly inhibits caspase 9. Z-FA-FMKis considered to be a negative control for FMK based caspase inhibitors.
Details of Functionality
Mass Spec: M+1=514.1 Chromatography: TLC:Rf: 0.4 Single Spot, EtOAC:6, ACOH:0.1 H NMR: All functional groups are present
Content
Q-Val-Asp(non-omethylated)-OPH, also known as Q-VD(non-omethylated)-OPH. Molecular Weight: 513
Application Notes
Q-VD-OPH is a novel, irreversible, pan caspase inhibitor specifically designed for in vivo and in vitro research. Q-VD-OPH is widely cited in the literature, and researchers should refer to the literature for additional information about the various species that Q-VD-OPH has been used for.For in vitro applications, Q-VD-OPH is typically used at final working concentration of 10-100 uM. The variability depends on model system, including cell type, culture, properties, and type of apoptosis induction treatments. Each researcher should empirically establish optimal working concentrations for their in vitro model system. For in vivo applications, the recommended dose of Q-VD-OPh is 20 mg/kg. The caspase inhibitor is administered IP in 80-100% DMSO. Doses of up to 120 mg/kg have been used in mice without toxic effects (Melnikov and Vyacheslav, 2002; Patil and Sharma, 2004). Each researcher should empirically establish optimal doses for their animal model system. Use in functional reported in scientific literature (PMID: 24068677)
Publications
ReadPublications using NBP2-29391 in the following applications:
  • Func
    1 publication
  • WB
    1 publication
品牌介绍

About

Novus Biologicals

Accelerate Scientific Discovery by Developing Unique Products

The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products for the lifesciences. Novus Biologicals is also organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research.

All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving both niche and emerging markets, Novus Biologicals has built solid partnerships with our customers. Contact us for more information.

Novus Biologcials is part of the Bio-Techne family which includes:

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